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LMNA Antibody

CAT: 0223-59-797Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-797Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
NCBI Gene ID
4000
Swiss Prot
P02545
Accession Number
P02545
Host
Rabbit
Reactivity
Human
Immunogen
This LMNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-427 amino acids from the Central region of human LMNA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
74 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
LMNA
NCBI Official Name
Prelamin-A/C
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Wegner, L., et al. J. Clin. Endocrinol. Metab. 95 (8) :3884-3892 (2010)
Background Reference 03
Drac, H., et al. Neurol. Neurochir. Pol. 44 (3) :291-296 (2010)
Background Reference 04
Liu, Q., et al. PLoS ONE (5), E10874 (2010) :
Other Product Names
Prelamin-A/C, Lamin-A/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1
Tested Applications
WB
Protein ID
125962
Physical Properties
Liquid

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