AFF2 Antibody

• Background:

  This gene encodes a putative transcriptional activator that is a member of the AF4FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked mental retardation. Alternate splicing results in multiple transcript variants.

• NCBI Gene ID:

  2334

• Swiss Prot:

  P51816

• Accession Number:

  P51816

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This AFF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 886-912 amino acids from the Central region of human AFF2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  145 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  AFF2

• NCBI Official Name:

  AF4/FMR2 family member 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bensaid, M., et al. Nucleic Acids Res. 37 (4) :1269-1279 (2009)

• Background Reference 02:

  Brylawski, B.P., et al. Exp. Mol. Pathol. 82 (2) :190-196 (2007)

• Background Reference 03:

  Sharma, D., et al. Genet. Epidemiol. 20 (1) :129-144 (2001)

• Background Reference 04:

  Hillman, M.A., et al. J. Hum. Genet. 46 (5) :251-259 (2001)

• Other Product Names:

  AF4/FMR2 family member 2, Fragile X E mental retardation syndrome protein, Fragile X mental retardation 2 protein, FMR2P, Protein FMR-2, Protein Ox19, AFF2, FMR2, OX19

• Tested Applications:

  WB

• Protein ID:

  116241242

• Physical Properties:

  Liquid