AFF1 Antibody

• Background :

  This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID :

  4299

• Swiss Prot :

  P51825

• Host :

  Rabbit

• Reactivity :

  Human, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 1124-1218 of human AFF1 (NP_001160165.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Transcription

• Purification :

  Affinity purification

• Positive Control :

  SW480

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 135kDa

• Fragment :

  IgG

• Symbol :

  AFF1

• Positive Control 2 :

  BT474

• NCBI Official Name :

  AF4/FMR2 family, member 1

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  AFF1, AF4/FMR2 family, member 1, AF-4, AF4, AF4/FMR2 family member 1, FEL, PBM1, Protein FEL, MLLT2, Unknown, Protein AF-4, Proto-oncogene AF4

• Tested Applications :

  WB, IHC, IF

• Physical Properties :

  Liquid