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DMGDH Antibody

CAT: 0223-59-586Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-586Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum.
NCBI Gene ID
29958
Swiss Prot
Q9UI17
Accession Number
Q9UI17
Host
Rabbit
Reactivity
Human
Immunogen
This DMGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 836-864 amino acids from the C-terminal region of human DMGDH.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
97 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
DMGDH
NCBI Official Name
Dimethylglycine dehydrogenase, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Mostowska, A., et al. Eur. J. Oral Sci. 118 (4) :325-332 (2010)
Background Reference 02
Bailey, S.D., et al. Diabetes Care (2010) In press :
Background Reference 03
Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :
Background Reference 04
Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)
Other Product Names
Dimethylglycine dehydrogenase, mitochondrial, ME2GLYDH, DMGDH
Tested Applications
WB
Protein ID
296434575
Physical Properties
Liquid

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