NEO1 Antibody

• Background:

  This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq].

• NCBI Gene ID:

  4756

• Swiss Prot:

  Q92859

• Accession Number:

  Q92859

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This NEO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 657-685 amino acids from the Central region of human NEO1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  160 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  NEO1

• NCBI Official Name:

  Neogenin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bradford, D., et al. J. Comp. Neurol. 518 (16) :3237-3253 (2010)

• Background Reference 02:

  Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

• Background Reference 03:

  Zhang, A.S., et al. J. Biol. Chem. 284 (34) :22580-22589 (2009)

• Background Reference 04:

  Fujita, Y., et al. Cell Death Differ. 15 (10) :1593-1608 (2008)

• Other Product Names:

  Neogenin, Immunoglobulin superfamily DCC subclass member 2, NEO1, IGDCC2, NGN

• Tested Applications:

  WB

• Protein ID:

  116242676

• Physical Properties:

  Liquid