LPHN3 Antibody

• Background:

  This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR) . Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.

• NCBI Gene ID:

  23284

• Swiss Prot:

  Q9HAR2

• Accession Number:

  Q9HAR2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This LPHN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 371-397 amino acids from the N-terminal region of human LPHN3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Growth Factors

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  162 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  LPHN3

• NCBI Official Name:

  Latrophilin-3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Arcos-Burgos, M., et al. Mol. Psychiatry 15 (11) :1053-1066 (2010)

• Background Reference 02:

  Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

• Background Reference 03:

  Kasperaviciute, D., et al. Brain 133 (PT 7), 2136-2147 (2010) :

• Background Reference 04:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Other Product Names:

  Latrophilin-3, Calcium-independent alpha-latrotoxin receptor 3, CIRL-3, Lectomedin-3, LPHN3, KIAA0768, LEC3

• Tested Applications:

  WB

• Protein ID:

  47116772

• Physical Properties:

  Liquid