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RGL4 Antibody

CAT: 0223-59-314Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-314Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ral GDS (Ral guanine nucleotide dissociation stimulator) is a guanine nucleotide exchange factor (GEF) that activates Ral and is implicated in oncogenic Ras-induced cell transformation. RGL4 (ral guanine nucleotide dissociation stimulator-like 4), also known as Rgr, is a 473 amino acid protein that localizes to the cytoplasmic vesicle of cells. Belonging to the GEF family of proteins, RGL4 induces phosphorylation of ERKs, p38 and JNK kinases, and it increases the levels of GTP bound forms of Ral and Ras. Ras activation is crucial for the transforming activity of RGL4. Due to its similarity to Ral GDS, RGL4 may be implicated in carcinogenesis.
NCBI Gene ID
266747
Swiss Prot
Q8IZJ4
Accession Number
Q8IZJ4
Host
Rabbit
Reactivity
Human
Immunogen
This RGL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-125 amino acids from the N-terminal region of human RGL4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
52 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RGL4
NCBI Official Name
Ral-GDS-related protein
NCBI Organism
Homo sapiens
Background Reference 01
Hernandez-Munoz, I., et al. Cancer Res. 63 (14) :4188-4195 (2003)
Background Reference 02
Hernandez-Munoz, I., et al. Oncogene 19 (23) :2745-2757 (2000)
Background Reference 03
Dunham, I., et al. Nature 402 (6761) :489-495 (1999)
Background Reference 04
D'Adamo, D.R., et al. Oncogene 14 (11) :1295-1305 (1997)
Other Product Names
Ral-GDS-related protein, hRGR, Ral guanine nucleotide dissociation stimulator-like 4, RalGDS-like 4, RGL4, RGR
Tested Applications
WB
Protein ID
34222891
Physical Properties
Liquid

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