DPF1 Antibody

• Background:

  DPF1 may have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) . During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF) . The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity) .

• NCBI Gene ID:

  8193

• Swiss Prot:

  Q92782

• Accession Number:

  Q92782

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DPF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 220-247 amino acids from the Central region of human DPF1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  43 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DPF1

• NCBI Official Name:

  Zinc finger protein neuro-d4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gudmundsson, J., et al. Nat. Genet. 41 (10) :1122-1126 (2009)

• Background Reference 02:

  Chestkov, A.V., et al. Genomics 36 (1) :174-177 (1996)

• Other Product Names:

  Zinc finger protein neuro-d4, BRG1-associated factor 45B, BAF45B, D4, zinc and double PHD fingers family 1, DPF1, BAF45B, NEUD4

• Tested Applications:

  WB

• Protein ID:

  313104100

• Physical Properties:

  Liquid