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DPF1 Antibody

CAT: 0223-59-261Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-261Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DPF1 may have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) . During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF) . The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity) .
NCBI Gene ID
8193
Swiss Prot
Q92782
Accession Number
Q92782
Host
Rabbit
Reactivity
Human
Immunogen
This DPF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 220-247 amino acids from the Central region of human DPF1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
43 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
DPF1
NCBI Official Name
Zinc finger protein neuro-d4
NCBI Organism
Homo sapiens
Background Reference 01
Gudmundsson, J., et al. Nat. Genet. 41 (10) :1122-1126 (2009)
Background Reference 02
Chestkov, A.V., et al. Genomics 36 (1) :174-177 (1996)
Other Product Names
Zinc finger protein neuro-d4, BRG1-associated factor 45B, BAF45B, D4, zinc and double PHD fingers family 1, DPF1, BAF45B, NEUD4
Tested Applications
WB
Protein ID
313104100
Physical Properties
Liquid

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