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SOST Antibody

CAT: 0223-59-168Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-168Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq].
NCBI Gene ID
50964
Swiss Prot
Q9BQB4
Accession Number
Q9BQB4
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This SOST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-66 amino acids from the N-terminal region of human SOST.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
24 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:500
Symbol
SOST
NCBI Official Name
Sclerostin
NCBI Organism
Homo sapiens
Background Reference 01
Van Lierop, A.H., et al. Eur. J. Endocrinol. 163 (5) :833-837 (2010)
Background Reference 02
Liu, J.M., et al. J. Clin. Endocrinol. Metab. 95 (9), E112-E120 (2010) :
Background Reference 03
Paternoster, L., et al. J. Clin. Endocrinol. Metab. 95 (8) :3940-3948 (2010)
Background Reference 04
Piters, E., et al. Hum. Mutat. 31 (7), E1526-E1543 (2010) :
Other Product Names
Sclerostin, SOST
Tested Applications
WB
Protein ID
20140220
Physical Properties
Liquid

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