SOST Antibody

• Background:

  Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq].

• NCBI Gene ID:

  50964

• Swiss Prot:

  Q9BQB4

• Accession Number:

  Q9BQB4

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This SOST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-66 amino acids from the N-terminal region of human SOST.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  24 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:500

• Symbol:

  SOST

• NCBI Official Name:

  Sclerostin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Van Lierop, A.H., et al. Eur. J. Endocrinol. 163 (5) :833-837 (2010)

• Background Reference 02:

  Liu, J.M., et al. J. Clin. Endocrinol. Metab. 95 (9), E112-E120 (2010) :

• Background Reference 03:

  Paternoster, L., et al. J. Clin. Endocrinol. Metab. 95 (8) :3940-3948 (2010)

• Background Reference 04:

  Piters, E., et al. Hum. Mutat. 31 (7), E1526-E1543 (2010) :

• Other Product Names:

  Sclerostin, SOST

• Tested Applications:

  WB

• Protein ID:

  20140220

• Physical Properties:

  Liquid