RRN3 Antibody

• Background:

  Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC) . Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity) .

• NCBI Gene ID:

  54700

• Swiss Prot:

  Q9NYV6

• Accession Number:

  Q9NYV6

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This RRN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-305 amino acids from the Central region of human RRN3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  74 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  RRN3

• NCBI Official Name:

  RNA polymerase I-specific transcription initiation factor RRN3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bierhoff, H., et al. Mol. Cell. Biol. 28 (16) :4988-4998 (2008)

• Background Reference 02:

  Amit, M., et al. BMC Mol. Biol. 8, 109 (2007) :

• Background Reference 03:

  Mayer, C., et al. Genes Dev. 18 (4) :423-434 (2004)

• Background Reference 04:

  Hirschler-Laszkiewicz, I., et al. J. Biol. Chem. 278 (21) :18953-18959 (2003)

• Other Product Names:

  RNA polymerase I-specific transcription initiation factor RRN3, Transcription initiation factor IA, TIF-IA, RRN3, TIFIA

• Tested Applications:

  WB

• Protein ID:

  74719591

• Physical Properties:

  Liquid