ASB2 Antibody

• Background :

  The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.

• NCBI Gene ID :

  51676

• Swiss Prot :

  Q96Q27

• Accession Number :

  Q96Q27

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This ASB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the N-terminal region of human ASB2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  65 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  ASB2

• NCBI Official Name :

  Ankyrin repeat and SOCS box protein 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Heuze, M.L., et al. Blood 112 (13) :5130-5140 (2008)

• Background Reference 02 :

  Kohroki, J., et al. FEBS Lett. 579 (30) :6796-6802 (2005)

• Background Reference 03 :

  Heuze, M.L., et al. J. Biol. Chem. 280 (7) :5468-5474 (2005)

• Background Reference 04 :

  Colland, F., et al. Genome Res. 14 (7) :1324-1332 (2004)

• Other Product Names :

  Ankyrin repeat and SOCS box protein 2, ASB-2, ASB2

• Tested Applications :

  WB

• Protein ID :

  20531999

• Physical Properties :

  Liquid