OS9 Antibody

• Background:

  This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

• NCBI Gene ID:

  10956

• Swiss Prot:

  Q13438

• Accession Number:

  Q13438

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This OS9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 amino acids from the C-terminal region of human OS9.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  76 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  OS9

• NCBI Official Name:

  Protein OS-9

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Feng, T., et al. Hum. Genet. 128 (3) :269-280 (2010)

• Background Reference 02:

  Mikami, K., et al. Glycobiology 20 (3) :310-321 (2010)

• Background Reference 03:

  Hosokawa, N., et al. J. Biol. Chem. 284 (25) :17061-17068 (2009)

• Background Reference 04:

  Jansen, B.J., et al. Mol. Immunol. 46 (4) :505-515 (2009)

• Other Product Names:

  Protein OS-9, Amplified in osteosarcoma 9, OS9

• Tested Applications:

  WB

• Protein ID:

  3024310

• Physical Properties:

  Liquid