CDC14A Antibody

• Background:

  The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq].

• NCBI Gene ID:

  8556

• Swiss Prot:

  Q9UNH5

• Accession Number:

  Q9UNH5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CDC14A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473-500 amino acids from the C-terminal region of human CDC14A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  67 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CDC14A

• NCBI Official Name:

  Dual specificity protein phosphatase CDC14A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 02:

  Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :

• Background Reference 03:

  Mocciaro, A., et al. J. Cell Biol. 189 (4) :631-639 (2010)

• Background Reference 04:

  Song, S.Y., et al. APMIS 118 (5) :389-393 (2010)

• Other Product Names:

  Dual specificity protein phosphatase CDC14A, CDC14 cell division cycle 14 homolog A, CDC14A

• Tested Applications:

  WB

• Protein ID:

  55976620

• Physical Properties:

  Liquid