Cdc14 Antibody

• Background:

  The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.

• NCBI Gene ID:

  8556

• Swiss Prot:

  Q9UNH5

• Accession Number:

  Q9UNH5

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This Cdc14 antibody is generated from rabbits immunized with a recombinant protein encoding aa 1~379 of human cdc14.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by dialysis against PBS

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  67 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CDC14A

• NCBI Official Name:

  Dual specificity protein phosphatase CDC14A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kaiser, B.K., et al. Mol. Biol. Cell 13 (7), 2289-2300 (2002)

• Background Reference 02:

  Mailand, N., et al. Nat. Cell Biol. (4), 317-322 (2002)

• Background Reference 03:

  Bembenek, J. and Yu, H. J. Biol. Chem. 276 (51), 48237-48242 (2001)

• Background Reference 04:

  Li, L., et al. J. Biol. Chem. 275 (4), 2410-2414 (2000)

• Other Product Names:

  Dual specificity protein phosphatase CDC14A, CDC14 cell division cycle 14 homolog A, CDC14A

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  55976620

• Physical Properties:

  Liquid