ITM2C Antibody

• Background:

  Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity) .

• NCBI Gene ID:

  81618

• Swiss Prot:

  Q9NQX7

• Accession Number:

  Q9NQX7

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ITM2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-55 amino acids from the N-terminal region of human ITM2C.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Monkey

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  30 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ITM2C

• NCBI Official Name:

  Integral membrane protein 2C

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yoshida, T., et al. Int. J. Mol. Med. 25 (4) :649-656 (2010)

• Background Reference 02:

  Oguri, M., et al. Am. J. Hypertens. 23 (1) :70-77 (2010)

• Background Reference 03:

  Matsuda, S., et al. J. Biol. Chem. 284 (23) :15815-15825 (2009)

• Background Reference 04:

  Matsuda, S., et al. Mol Neurodegener 4, 41 (2009) :

• Other Product Names:

  Integral membrane protein 2C, Cerebral protein 14, Transmembrane protein BRI3, CT-BRI3, ITM2C, BRI3

• Tested Applications:

  WB

• Protein ID:

  12585259

• Physical Properties:

  Liquid