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ITM2C Antibody

CAT: 0223-59-012Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-012Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity) .
NCBI Gene ID
81618
Swiss Prot
Q9NQX7
Accession Number
Q9NQX7
Host
Rabbit
Reactivity
Human
Immunogen
This ITM2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-55 amino acids from the N-terminal region of human ITM2C.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
30 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ITM2C
NCBI Official Name
Integral membrane protein 2C
NCBI Organism
Homo sapiens
Background Reference 01
Yoshida, T., et al. Int. J. Mol. Med. 25 (4) :649-656 (2010)
Background Reference 02
Oguri, M., et al. Am. J. Hypertens. 23 (1) :70-77 (2010)
Background Reference 03
Matsuda, S., et al. J. Biol. Chem. 284 (23) :15815-15825 (2009)
Background Reference 04
Matsuda, S., et al. Mol Neurodegener 4, 41 (2009) :
Other Product Names
Integral membrane protein 2C, Cerebral protein 14, Transmembrane protein BRI3, CT-BRI3, ITM2C, BRI3
Tested Applications
WB
Protein ID
12585259
Physical Properties
Liquid

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