ITM2B Antibody

• Background :

  Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

• NCBI Gene ID :

  9445

• Swiss Prot :

  Q9Y287

• Accession Number :

  Q9Y287

• Host :

  Rabbit

• Reactivity :

  Mouse

• Immunogen :

  This ITM2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-247 amino acids from the C-terminal region of human ITM2B.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Monkey

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  30 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  ITM2B

• NCBI Official Name :

  Integral membrane protein 2B

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Peng, S., et al. Biochem. Biophys. Res. Commun. 393 (3) :356-361 (2010)

• Background Reference 02 :

  Matsuda, S., et al. J. Biol. Chem. 284 (23) :15815-15825 (2009)

• Background Reference 03 :

  Matsuda, S., et al. Mol Neurodegener 4, 41 (2009) :

• Background Reference 04 :

  Tsachaki, M., et al. Biotechnol3 (12) :1548-1554 (2008)

• Other Product Names :

  Integral membrane protein 2B, Immature BRI2, imBRI2, Protein E25B, Transmembrane protein BRI, Bri, BRI2, membrane form, Mature BRI2, mBRI2, BRI2 intracellular domain, BRI2 ICD, BRI2C, soluble form, Bri23 peptide, Bri2-23, ABri23, C-terminal peptide, P23 peptide, ITM2B, BRI, BRI2

• Tested Applications :

  WB, IHC-P

• Protein ID :

  12643343

• Physical Properties :

  Liquid