ITM2B Antibody

• Background:

  Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

• NCBI Gene ID:

  9445

• Swiss Prot:

  Q9Y287

• Accession Number:

  Q9Y287

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This ITM2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-247 amino acids from the C-terminal region of human ITM2B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Monkey

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  30 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ITM2B

• NCBI Official Name:

  Integral membrane protein 2B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Peng, S., et al. Biochem. Biophys. Res. Commun. 393 (3) :356-361 (2010)

• Background Reference 02:

  Matsuda, S., et al. J. Biol. Chem. 284 (23) :15815-15825 (2009)

• Background Reference 03:

  Matsuda, S., et al. Mol Neurodegener 4, 41 (2009) :

• Background Reference 04:

  Tsachaki, M., et al. Biotechnol3 (12) :1548-1554 (2008)

• Other Product Names:

  Integral membrane protein 2B, Immature BRI2, imBRI2, Protein E25B, Transmembrane protein BRI, Bri, BRI2, membrane form, Mature BRI2, mBRI2, BRI2 intracellular domain, BRI2 ICD, BRI2C, soluble form, Bri23 peptide, Bri2-23, ABri23, C-terminal peptide, P23 peptide, ITM2B, BRI, BRI2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  12643343

• Physical Properties:

  Liquid