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ITM2B Antibody

CAT: 0223-56-894Size: 400 µLDry Ice: NoHazardous: No
CAT#: 56-894Size: 400 µL
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
NCBI Gene ID
9445
Swiss Prot
Q9Y287
Accession Number
Q9Y287
Host
Rabbit
Reactivity
Mouse
Immunogen
This ITM2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-247 amino acids from the C-terminal region of human ITM2B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
30 kDa
Fragment
Rabbit Ig
Symbol
ITM2B
NCBI Official Name
Integral membrane protein 2B
NCBI Organism
Homo sapiens
Background Reference 01
Peng, S., et al. Biochem. Biophys. Res. Commun. 393 (3) :356-361 (2010)
Background Reference 02
Matsuda, S., et al. J. Biol. Chem. 284 (23) :15815-15825 (2009)
Background Reference 03
Matsuda, S., et al. Mol Neurodegener 4, 41 (2009) :
Background Reference 04
Tsachaki, M., et al. Biotechnol3 (12) :1548-1554 (2008)
Other Product Names
Integral membrane protein 2B, Immature BRI2, imBRI2, Protein E25B, Transmembrane protein BRI, Bri, BRI2, membrane form, Mature BRI2, mBRI2, BRI2 intracellular domain, BRI2 ICD, BRI2C, soluble form, Bri23 peptide, Bri2-23, ABri23, C-terminal peptide, P23 peptide, ITM2B, BRI, BRI2
Tested Applications
WB, IHC-P
Protein ID
12643343
Physical Properties
Liquid

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