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BRCA1 Antibody

CAT: 0223-58-979Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-979Size:400 µL
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Background
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC) . This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq].
NCBI Gene ID
672
Swiss Prot
P38398
Accession Number
P38398
Host
Rabbit
Reactivity
Human
Immunogen
This BRCA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 443-472 amino acids from the N-terminal region of human BRCA1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
208 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
BRCA1
NCBI Official Name
Breast cancer type 1 susceptibility protein
NCBI Organism
Homo sapiens
Background Reference 01
Matsuoka, S., et al. Science 316 (5828) :1160-1166 (2007)
Background Reference 02
Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)
Background Reference 03
Fabbro, M., et al. J. Biol. Chem. 279 (30) :31251-31258 (2004)
Background Reference 04
Ouchi, M., et al. J. Biol. Chem. 279 (19) :19643-19648 (2004)
Other Product Names
Breast cancer type 1 susceptibility protein, 632-, RING finger protein 53, BRCA1, RNF53
Tested Applications
WB
Protein ID
728984
Physical Properties
Liquid

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