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CDC42EP2 Antibody

CAT: 0223-58-973Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-973Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. Coexpression of this protein with dominant negative mutant CDC42 protein in fibroblast was found to induce pseudopodia formation, which suggested a role of this protein in actin filament assembly and cell shape control.
NCBI Gene ID
10435
Swiss Prot
O14613
Accession Number
O14613
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This CDC42EP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-160 amino acids from the C-terminal region of human CDC42EP2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
22 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CDC42EP2
NCBI Official Name
Cdc42 effector protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Xue, Y., et al. Int. J. Cancer 118 (12) :2965-2972 (2006)
Background Reference 02
Joberty, G., et al. Nat. Cell Biol. 3 (10) :861-866 (2001)
Background Reference 03
Hirsch, D.S., et al. J. Biol. Chem. 276 (2) :875-883 (2001)
Background Reference 04
Joberty, G., et al. Mol. Cell. Biol. 19 (10) :6585-6597 (1999)
Other Product Names
Cdc42 effector protein 2, Binder of Rho GTPases 1, CDC42EP2, BORG1, CEP2
Tested Applications
WB
Physical Properties
Liquid

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