TPBG Antibody

• Background:

  This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq].

• NCBI Gene ID:

  7162

• Swiss Prot:

  Q13641

• Accession Number:

  Q13641

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TPBG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-197 amino acids from the Central region of human TPBG.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  46 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TPBG

• NCBI Official Name:

  Trophoblast glycoprotein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Elkord, E., et al. J. Immunother. 31 (9) :820-829 (2008)

• Background Reference 02:

  Shingler, W.H., et al. Int. Immunol. 20 (8) :1057-1066 (2008)

• Background Reference 03:

  Okazaki, S., et al. Obstet Gynecol 110 (5) :1130-1136 (2007)

• Background Reference 04:

  Ward, C.M., et al. Exp. Cell Res. 312 (10) :1713-1726 (2006)

• Other Product Names:

  Trophoblast glycoprotein, 5T4 oncofetal antigen, 5T4 oncofetal trophoblast glycoprotein, 5T4 oncotrophoblast glycoprotein, M6P1, Wnt-activated inhibitory factor 1, WAIF1, TPBG, 5T4

• Tested Applications:

  WB

• Protein ID:

  73621980

• Physical Properties:

  Liquid