TJP2 Antibody

• Background:

  This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutation in this gene have been identified in patients with hypercholanemia. Alternate splicing results in multiple transcript variants.

• NCBI Gene ID:

  9414

• Swiss Prot:

  Q9UDY2

• Accession Number:

  Q9UDY2

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TJP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 981-1009 amino acids from the C-terminal region of human TJP2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  134 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TJP2

• NCBI Official Name:

  Tight junction protein ZO-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lechuga, S., et al. Exp. Cell Res. 316 (19) :3124-3139 (2010)

• Background Reference 02:

  Remue, E., et al. FEBS Lett. 584 (19) :4175-4180 (2010)

• Background Reference 03:

  Walsh, T., et al. Am. J. Hum. Genet. 87 (1) :101-109 (2010)

• Background Reference 04:

  Meerschaert, K., et al. Cell. Mol. Life Sci. 66 (24) :3951-3966 (2009)

• Other Product Names:

  Tight junction protein ZO-2, Tight junction protein 2, Zona occludens protein 2, Zonula occludens protein 2, TJP2, X104, ZO2

• Tested Applications:

  WB

• Protein ID:

  317373313

• Physical Properties:

  Liquid