LDB3 Antibody

• Background:

  This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq].

• NCBI Gene ID:

  11155

• Swiss Prot:

  O75112

• Accession Number:

  O75112

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This LDB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-262 amino acids from the Central region of human LDB3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  77 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  LDB3

• NCBI Official Name:

  LIM domain-binding protein 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lechuga, S., et al. Exp. Cell Res. 316 (19) :3124-3139 (2010)

• Background Reference 02:

  Zimmerman, R.S., et al. Genet. Med. 12 (5) :268-278 (2010)

• Background Reference 03:

  Vihola, A., et al. Acta Neuropathol. 119 (4) :465-479 (2010)

• Background Reference 04:

  Rampersaud, E., et al. Ann. Hum. Genet. 74 (2) :110-116 (2010)

• Other Product Names:

  HGNC:15710

• Tested Applications:

  WB

• Physical Properties:

  Liquid