LDB3 Antibody

• Background:

  This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains.

• NCBI Gene ID:

  11155

• Swiss Prot:

  O75112

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human LDB3 (NP_001073585.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  HL-60

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 50kDa/90kDa

• Fragment:

  IgG

• Symbol:

  LDB3

• Positive Control 2:

  MCF7

• Positive Control 3:

  U-937

• Positive Control 4:

  Raji

• Positive Control 5:

  BT-474

• Positive Control 6:

  Mouse skeletal muscle

• NCBI Official Name:

  LIM domain binding 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  LDB3, CYPHER, KIAA01613, KIAA0613, ORACLE, PDLIM6, ZASP, MFM4, CMD1C, LVNC3, LDB3Z1, LDB3Z4

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid