ARAP2 Antibody

• Background:

  The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5) -trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics.

• NCBI Gene ID:

  116984

• Swiss Prot:

  Q8WZ64

• Accession Number:

  Q8WZ64

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ARAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-93 amino acids from the N-terminal region of human ARAP2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  193 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ARAP2

• NCBI Official Name:

  Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gavicherla, B., et al. Infect. Immun. 78 (11) :4532-4541 (2010)

• Background Reference 02:

  Liu, C., et al. Mol. Med. 14 (9-10), 575-581 (2008) :

• Background Reference 03:

  Yoon, H.Y., et al. J. Cell. Sci. 119 (PT 22), 4650-4666 (2006) :

• Background Reference 04:

  Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

• Other Product Names:

  Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2, Centaurin-delta-1, Cnt-d1, Protein PARX, ARAP2, CENTD1, KIAA0580

• Tested Applications:

  WB

• Protein ID:

  308153629

• Physical Properties:

  Liquid