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PTPN18 Antibody

CAT: 0223-58-809Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-809Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
NCBI Gene ID
26469
Swiss Prot
Q99952
Accession Number
Q99952
Host
Rabbit
Reactivity
Human
Immunogen
This PTPN18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 430-459 amino acids from the C-terminal region of human PTPN18.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
50 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PTPN18
NCBI Official Name
Tyrosine-protein phosphatase non-receptor type 18
NCBI Organism
Homo sapiens
Background Reference 01
Oh, J.H., et al. Mamm. Genome 16 (12) :942-954 (2005)
Background Reference 02
Zhang, Y., et al. Mol. Cell Proteomics 4 (9) :1240-1250 (2005)
Background Reference 03
Tao, W.A., et al. Nat. Methods 2 (8) :591-598 (2005)
Background Reference 04
Blanchetot, C., et al. Methods 35 (1) :44-53 (2005)
Other Product Names
Tyrosine-protein phosphatase non-receptor type 18, Brain-derived phosphatase, PTPN18, BDP1
Tested Applications
WB
Protein ID
215273871
Physical Properties
Liquid

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