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PTPN13 Antibody

CAT: 0223-14-741Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-14-741Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
NCBI Gene ID
5783
Swiss Prot
Q12923
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human PTPN13 (NP_542416.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology, Signal Transduction
Purification
Affinity purification
Positive Control
293T
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 310kDa
Fragment
IgG
Symbol
PTPN13
Positive Control 2
A-549
Positive Control 3
U-87MG
Positive Control 4
Mouse kidney
Positive Control 5
Mouse lung
Positive Control 6
Mouse heart
NCBI Official Name
Protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas) -associated phosphatase)
NCBI Organism
Homo sapiens
Other Product Names
PTPN13, FAP-1, HPTP1E, HPTPE1, Fas associated phosphatase 1, Phosphatase rip, PTP-BAS, PTP-E1, PTP-BL, PTP1E, PTPLE, PNP1, PTPL1
Tested Applications
WB, IHC, IF
Physical Properties
Liquid

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