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PRKAG3 Antibody

CAT: 0223-58-783Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-783Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq].
NCBI Gene ID
53632
Swiss Prot
Q9UGI9
Accession Number
Q9UGI9
Host
Rabbit
Reactivity
Human
Immunogen
This PRKAG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 426-454 amino acids from the C-terminal region of human PRKAG3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
54 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PRKAG3
NCBI Official Name
5'-AMP-activated protein kinase subunit gamma-3
NCBI Organism
Homo sapiens
Background Reference 01
Jablonski, K.A., et al. Diabetes 59 (10) :2672-2681 (2010)
Background Reference 02
Jassim, G., et al. Pharmacopsychiatry (2010) In press :
Background Reference 03
Crawford, S.A., et al. Diabetologia 53 (9) :1986-1997 (2010)
Background Reference 04
Ramanathan, L., et al. Protein Expr. Purif. 70 (1) :13-22 (2010)
Other Product Names
5'-AMP-activated protein kinase subunit gamma-3, AMPK gamma3, AMPK subunit gamma-3, PRKAG3, AMPKG3
Tested Applications
WB
Protein ID
85681287
Physical Properties
Liquid

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