TTC8 Antibody

• Background:

  This gene encodes a protein that has been directly linked to Bardet-Biedl syndrome. The primary features of this syndrome include retinal dystrophy, obesity, polydactyly, renal abnormalities and learning disabilities. Experimentation in non-human eukaryotes suggests that this gene is expressed in ciliated cells and that it is involved in the formation of cilia. Alternate transcriptional splice variants have been characterized.

• NCBI Gene ID:

  123016

• Swiss Prot:

  Q8TAM2

• Accession Number:

  Q8TAM2

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TTC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human TTC8.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  62 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TTC8

• NCBI Official Name:

  Tetratricopeptide repeat protein 8

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Riazuddin, S.A., et al. Am. J. Hum. Genet. 86 (5) :805-812 (2010)

• Background Reference 02:

  Bin, J., et al. Hum. Mutat. 30 (7), E737-E746 (2009) :

• Background Reference 03:

  Chung, W.K., et al. Hum. Hered. 67 (3) :193-205 (2009)

• Background Reference 04:

  Nachury, M.V., et al. Cell 129 (6) :1201-1213 (2007)

• Other Product Names:

  Tetratricopeptide repeat protein 8, TPR repeat protein 8, Bardet-Biedl syndrome 8 protein, TTC8, BBS8

• Tested Applications:

  WB

• Protein ID:

  308153511

• Physical Properties:

  Liquid