NPRL2 Antibody

• Background:

  Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.

• NCBI Gene ID:

  10641

• Swiss Prot:

  Q8WTW4

• Accession Number:

  Q8WTW4

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This NPRL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-373 amino acids from the C-terminal region of human NPRL2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  44 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  NPRL2

• NCBI Official Name:

  Nitrogen permease regulator 2-like protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Spielewoy, N., et al. Eukaryotic Cell 9 (4) :592-601 (2010)

• Background Reference 02:

  Otani, S., et al.Surg Oncol 100 (5) :358-363 (2009)

• Background Reference 03:

  Neklesa, T.K., et al. PLoS Genet. (6), E1000515 (2009) :

• Background Reference 04:

  Anedchenko, E.A., et al. Mol. Biol. (Mosk.) 42 (6) :965-976 (2008)

• Other Product Names:

  Nitrogen permease regulator 2-like protein, NPR2-like protein, Gene 21 protein, G21 protein, Tumor suppressor candidate 4, NPRL2, TUSC4

• Tested Applications:

  WB

• Protein ID:

  47117604

• Physical Properties:

  Liquid