P2RX1 Antibody

• Background:

  The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.

• NCBI Gene ID:

  5023

• Swiss Prot:

  P51575

• Accession Number:

  P51575

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This P2RX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-372 amino acids from the C-terminal region of human P2RX1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  45 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  P2RX1

• NCBI Official Name:

  P2X purinoceptor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Allsopp, R.C., et al. J. Biol. Chem. 285 (43) :32770-32777 (2010)

• Background Reference 02:

  Harper, M.T., et al. J. Thromb. Haemost. 8 (7) :1604-1613 (2010)

• Background Reference 03:

  Lalo, U., et al. J. Neurochem. 113 (5) :1177-1187 (2010)

• Background Reference 04:

  Varani, K., et al. Cell. Physiol. Biochem. 25 (2-3), 325-336 (2010) :

• Other Product Names:

  P2X purinoceptor 1, P2X1, ATP receptor, Purinergic receptor, P2RX1, P2X1

• Tested Applications:

  WB

• Protein ID:

  1709519

• Physical Properties:

  Liquid