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P2RX1 Antibody

CAT: 0223-58-729Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-729Size:400 µL
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Background
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.
NCBI Gene ID
5023
Swiss Prot
P51575
Accession Number
P51575
Host
Rabbit
Reactivity
Human
Immunogen
This P2RX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-372 amino acids from the C-terminal region of human P2RX1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
45 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
P2RX1
NCBI Official Name
P2X purinoceptor 1
NCBI Organism
Homo sapiens
Background Reference 01
Allsopp, R.C., et al. J. Biol. Chem. 285 (43) :32770-32777 (2010)
Background Reference 02
Harper, M.T., et al. J. Thromb. Haemost. 8 (7) :1604-1613 (2010)
Background Reference 03
Lalo, U., et al. J. Neurochem. 113 (5) :1177-1187 (2010)
Background Reference 04
Varani, K., et al. Cell. Physiol. Biochem. 25 (2-3), 325-336 (2010) :
Other Product Names
P2X purinoceptor 1, P2X1, ATP receptor, Purinergic receptor, P2RX1, P2X1
Tested Applications
WB
Protein ID
1709519
Physical Properties
Liquid