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P2RX3 Antibody

CAT: 0223-60-165Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-165Size:400 µL
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Background
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.
NCBI Gene ID
5024
Swiss Prot
P56373
Accession Number
P56373
Host
Rabbit
Reactivity
Human
Immunogen
This P2RX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-356 amino acids from the C-terminal region of human P2RX3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
P2RX3
NCBI Official Name
P2X purinoceptor 3
NCBI Organism
Homo sapiens
Background Reference 01
Allsopp, R.C., et al. J. Biol. Chem. 285 (43) :32770-32777 (2010)
Background Reference 02
Beneng, K., et al. IntOral Maxillofac Surg 39 (8) :815-819 (2010)
Background Reference 03
Nair, A., et al. Cell. Mol. Neurobiol. 30 (4) :505-509 (2010)
Background Reference 04
Jacques-Silva, M.C., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (14) :6465-6470 (2010)
Other Product Names
P2X purinoceptor 3, P2X3, ATP receptor, Purinergic receptor, P2RX3
Tested Applications
WB
Protein ID
259016295
Physical Properties
Liquid

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