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TOP3B Antibody

CAT: 0223-58-713Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-713Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.
NCBI Gene ID
8940
Swiss Prot
O95985
Accession Number
O95985
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This TOP3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 826-854 amino acids from the C-terminal region of human TOP3B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
97 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TOP3B
NCBI Official Name
DNA topoisomerase 3-beta-1
NCBI Organism
Homo sapiens
Background Reference 01
Oliveira-Costa, J.P., et al. Hum. Pathol. 41 (11) :1624-1630 (2010)
Background Reference 02
Lesch, K.P., et al.Neural Transm 115 (11) :1573-1585 (2008)
Background Reference 03
Cho, Y.H., et al. Biochim. Biophys. Acta 1679 (3) :272-278 (2004)
Background Reference 04
Lehner, B., et al. Genome Res. 14 (7) :1315-1323 (2004)
Other Product Names
DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1, TOP3B, TOP3B1
Tested Applications
WB
Physical Properties
Liquid

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