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FBXO5 Antibody

CAT: 0223-58-707Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-707Size:400 µL
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Background
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified.
NCBI Gene ID
26271
Swiss Prot
Q9UKT4
Accession Number
Q9UKT4
Host
Rabbit
Reactivity
Human
Immunogen
This FBXO5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-221 amino acids from the Central region of human FBXO5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
50 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
FBXO5
NCBI Official Name
F-box only protein 5
NCBI Organism
Homo sapiens
Background Reference 01
Lei, S.F., et al. J. Bone Miner. Res. (2010) In press :
Background Reference 02
Ma, H.T., et al. Mol. Cell. Biol. 29 (24) :6500-6514 (2009)
Background Reference 03
Lee, J., et al. Mol. Biol. Cell 20 (7) :1891-1902 (2009)
Background Reference 04
Gutgemann, I., et al. Mod. Pathol. 21 (4) :445-454 (2008)
Other Product Names
F-box only protein 5, Early mitotic inhibitor 1, FBXO5, EMI1, FBX5
Tested Applications
WB
Protein ID
24636847
Physical Properties
Liquid

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