PTPRN2 Antibody

• Background:

  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

• NCBI Gene ID:

  5799

• Swiss Prot:

  Q92932

• Accession Number:

  Q92932

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PTPRN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-189 amino acids from the N-terminal region of human PTPRN2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  111 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PTPRN2

• NCBI Official Name:

  Receptor-type tyrosine-protein phosphatase N2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 03:

  Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34 (5) :800-812 (2010)

• Background Reference 04:

  Yoshida, T., et al. Int. J. Mol. Med. 25 (4) :649-656 (2010)

• Other Product Names:

  Receptor-type tyrosine-protein phosphatase N2, R-PTP-N2, Islet cell autoantigen-related protein, IAR, ICAAR, Phogrin, PTPRN2, KIAA0387

• Tested Applications:

  WB

• Protein ID:

  116242738

• Physical Properties:

  Liquid