PTPRN Antibody

• Background:

  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.

• NCBI Gene ID:

  5798

• Swiss Prot:

  Q16849

• Accession Number:

  Q16849

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PTPRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-316 amino acids from the Central region of human PTPRN.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  106 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PTPRN

• NCBI Official Name:

  Receptor-type tyrosine-protein phosphatase-like N

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yu, L., et al. J. Immunol. Methods 353 (1-2), 20-23 (2010) :

• Background Reference 02:

  Honeyman, M.C., et al. J. Immunol. 184 (4) :2204-2210 (2010)

• Background Reference 03:

  Weenink, S.M., et al. J. Autoimmun. 33 (2) :147-154 (2009)

• Background Reference 04:

  Burbelo, P.D., et al. Diabetes Care 31 (9) :1824-1826 (2008)

• Other Product Names:

  Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512

• Tested Applications:

  WB

• Protein ID:

  2499754

• Physical Properties:

  Liquid