PTPRN Antibody

CAT: 0223-57-787Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-787Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.
NCBI Gene ID
5798
Swiss Prot
Q16849
Accession Number
Q16849
Host
Rabbit
Reactivity
Human
Immunogen
This PTPRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-316 amino acids from the Central region of human PTPRN.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
106 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PTPRN
NCBI Official Name
Receptor-type tyrosine-protein phosphatase-like N
NCBI Organism
Homo sapiens
Background Reference 01
Yu, L., et al. J. Immunol. Methods 353 (1-2), 20-23 (2010) :
Background Reference 02
Honeyman, M.C., et al. J. Immunol. 184 (4) :2204-2210 (2010)
Background Reference 03
Weenink, S.M., et al. J. Autoimmun. 33 (2) :147-154 (2009)
Background Reference 04
Burbelo, P.D., et al. Diabetes Care 31 (9) :1824-1826 (2008)
Other Product Names
Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512
Tested Applications
WB
Protein ID
2499754
Physical Properties
Liquid

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