CDCA4 Antibody

• Background:

  This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulaton of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1.

• NCBI Gene ID:

  55038

• Swiss Prot:

  Q9BXL8

• Accession Number:

  Q9BXL8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CDCA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-190 amino acids from the C-terminal region of human CDCA4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  26 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CDCA4

• NCBI Official Name:

  Cell division cycle-associated protein 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Tategu, M., et al. Biochimie 90 (10) :1515-1522 (2008)

• Background Reference 02:

  Wang, L., et al. Cell Motil. Cytoskeleton 65 (7) :581-593 (2008)

• Background Reference 03:

  Hayashi, R., et al. J. Biol. Chem. 281 (47) :35633-35648 (2006)

• Background Reference 04:

  Walker, M.G. Curr Cancer Drug Targets 1 (1) :73-83 (2001)

• Other Product Names:

  Cell division cycle-associated protein 4, Hematopoietic progenitor protein, CDCA4, HEPP

• Tested Applications:

  WB

• Protein ID:

  32699606

• Physical Properties:

  Liquid