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CDCA8 Antibody

CAT: 0223-4751-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-4751-01Size:0.02 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CDCA8 Antibody: CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.
NCBI Gene ID
55143
Swiss Prot
Q53HL2
Accession Number
NP_060571
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
CDCA8 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1465 - Rat Kidney Tissue Lysate
Concentration
1 mg/mL
Buffer
CDCA8 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CDCA8 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
CDCA8
NCBI Official Name
Cell division cycle associated 8
NCBI Organism
Homo sapiens
Background Reference 01
Gassmann R, Carvalho A, Hanzing AJ, et al. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J. Cell Biol.2004; 166:179-91.
Background Reference 02
Tani M, Okino N, Mitsutake S, et al. Molecular Cloning of the Full-length cDNA Encoding Mouse Neutral Ceramidase. J. Biol. Chem.2000; 275:11229-34.
Background Reference 03
Hanson KK, Kelley AC, and Bienz M Loss of Drosophila borealin causes polyploidy, delayed apoptosis and abnormal tissue development. Development2005; 132:4777-87.
Background Reference 04
Date DA, Jacob CJ, Bekier ME et al. Borealin is repressed in response to p53/Rb signaling. Cell Biol. Int.2007; 31:1470-81.
Other Product Names
CDCA8 Antibody: BOR, DasraB, MESRGP, BOREALIN, PESCRG3, Borealin, Cell division cycle-associated protein 8, hDasra-B
Tested Applications
ELISA, WB, IF
Protein ID
8922438
Physical Properties
Liquid

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