STAR Antibody

• Background:

  The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13.

• NCBI Gene ID:

  6770

• Swiss Prot:

  P49675

• Accession Number:

  P49675

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This STAR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 amino acids from the Central region of human STAR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  32 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  STAR

• NCBI Official Name:

  Steroidogenic acute regulatory protein, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Shi, F.T., et al. J. Clin. Endocrinol. Metab. 95 (10), E172-E180 (2010) :

• Background Reference 02:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 03:

  Mizutani, T., et al. J. Biol. Chem. 285 (36) :28240-28251 (2010)

• Background Reference 04:

  Sahakitrungruang, T., et al. J. Clin. Endocrinol. Metab. 95 (7) :3352-3359 (2010)

• Other Product Names:

  Steroidogenic acute regulatory protein, mitochondrial, StAR, START domain-containing protein 1, StARD1, STAR, STARD1

• Tested Applications:

  WB

• Protein ID:

  71152974

• Physical Properties:

  Liquid