ARNT2 Antibody

CAT: 0223-58-559Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-58-559Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.
NCBI Gene ID
9915
Swiss Prot
Q9HBZ2
Accession Number
Q9HBZ2
Host
Rabbit
Reactivity
Human
Immunogen
This ARNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-278 amino acids from the Central region of human ARNT2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
79 kDa
Fragment
Rabbit Ig
Symbol
ARNT2
NCBI Official Name
Aryl hydrocarbon receptor nuclear translocator 2
NCBI Organism
Homo sapiens
Background Reference 01
Ramirez, J.M., et al. Eur. J. Immunol. 40 (9) :2450-2459 (2010)
Background Reference 02
Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :
Background Reference 03
Chakrabarti, B., et al. Autism Res 2 (3) :157-177 (2009)
Background Reference 04
Ferreira, M.A., et al. Nat. Genet. 40 (9) :1056-1058 (2008)
Other Product Names
Aryl hydrocarbon receptor nuclear translocator 2, ARNT protein 2, Class E basic helix-loop-helix protein 1, bHLHe1, ARNT2, BHLHE1, KIAA0307
Tested Applications
WB, IF
Protein ID
125987793
Physical Properties
Liquid

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