ARNT2 Antibody

• Background:

  This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.

• NCBI Gene ID:

  9915

• Swiss Prot:

  Q9HBZ2

• Accession Number:

  Q9HBZ2

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ARNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-278 amino acids from the Central region of human ARNT2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  79 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ARNT2

• NCBI Official Name:

  Aryl hydrocarbon receptor nuclear translocator 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ramirez, J.M., et al. Eur. J. Immunol. 40 (9) :2450-2459 (2010)

• Background Reference 02:

  Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

• Background Reference 03:

  Chakrabarti, B., et al. Autism Res 2 (3) :157-177 (2009)

• Background Reference 04:

  Ferreira, M.A., et al. Nat. Genet. 40 (9) :1056-1058 (2008)

• Other Product Names:

  Aryl hydrocarbon receptor nuclear translocator 2, ARNT protein 2, Class E basic helix-loop-helix protein 1, bHLHe1, ARNT2, BHLHE1, KIAA0307

• Tested Applications:

  WB, IF

• Protein ID:

  125987793

• Physical Properties:

  Liquid