ARNT Antibody

• Background :

  This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID :

  405

• Swiss Prot :

  P27540

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  A synthetic peptide corresponding to a sequence within amino acids 400-500 of human ARNT (NP_001659.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Signal Transduction, Transcription

• Purification :

  Affinity purification

• Positive Control :

  HL-60

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 87kDa

• Fragment :

  IgG

• Symbol :

  ARNT

• Positive Control 2 :

  Mouse lung

• NCBI Official Name :

  Aryl hydrocarbon receptor nuclear translocator

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  ARNT, aryl hydrocarbon receptor nuclear translocator, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2, OTTHUMP00000218217, OTTHUMP00000218218, OTTHUMP00000218220, class E basic helix-loop-helix protein 2, dioxin receptor, nuclear transloc

• Tested Applications :

  WB, IHC

• Physical Properties :

  Liquid