BPNT1 Antibody

• Background:

  BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.

• NCBI Gene ID:

  10380

• Swiss Prot:

  O95861

• Accession Number:

  O95861

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This BPNT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-305 amino acids from the C-terminal region of human BPNT1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  33 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  BPNT1

• NCBI Official Name:

  3' (2'),5'-bisphosphate nucleotidase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Johnatty, S.E., et al. PLoS Genet. (7), E1001016 (2010) :

• Background Reference 02:

  Spiegelberg, B.D., et al. J. Biol. Chem. 274 (19) :13619-13628 (1999)

• Other Product Names:

  3' (2'),5'-bisphosphate nucleotidase 1, Bisphosphate 3'-nucleotidase 1, PAP-inositol 1,4-phosphatase, PIP, BPNT1

• Tested Applications:

  WB

• Physical Properties:

  Liquid