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ACCN4 Antibody

CAT: 0223-58-541Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-541Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. Alternative splicing at this locus results in two transcript variants encoding different isoforms.
NCBI Gene ID
55515
Swiss Prot
Q96FT7
Accession Number
Q96FT7
Host
Rabbit
Reactivity
Human
Immunogen
This ACCN4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-52 amino acids from the N-terminal region of human ACCN4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
70 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ASIC4
NCBI Official Name
Acid-sensing ion channel 4
NCBI Organism
Homo sapiens
Background Reference 01
Donier, E., et al. Eur. J. Neurosci. 28 (1) :74-86 (2008)
Background Reference 02
Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)
Background Reference 03
Hillier, L.W., et al. Nature 434 (7034) :724-731 (2005)
Background Reference 04
Grunder, S., et al. Eur. J. Hum. Genet. 9 (9) :672-676 (2001)
Other Product Names
Acid-sensing ion channel 4, ASIC4, Amiloride-sensitive cation channel 4, Amiloride-sensitive cation channel 4, pituitary, ASIC4, ACCN4
Tested Applications
WB
Protein ID
296434387
Physical Properties
Liquid

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