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CHD1L Antibody

CAT: 0223-58-475Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-475Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
In response to DNA strand breaks, chromatin adopts a relaxed structure due to the addition of poly (ADP-ribose) (PAR) to chromatin proteins by PARP enzymes (see PARP1; MIM 173870), and this relaxation facilitates the repair of DNA damage. CHD1L interacts with PAR and has a role in chromatin relaxation following DNA damage (Ahel et al., 2009 [PubMed 19661379]) .[supplied by OMIM].
NCBI Gene ID
9557
Swiss Prot
Q86WJ1
Accession Number
Q86WJ1
Host
Rabbit
Reactivity
Human
Immunogen
This CHD1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 561-590 amino acids from the Central region of human CHD1L.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
101 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CHD1L
NCBI Official Name
Chromodomain-helicase-DNA-binding protein 1-like
NCBI Organism
Homo sapiens
Background Reference 01
Liu, C.Y., et al. Carcinogenesis 31 (7) :1259-1263 (2010)
Background Reference 02
Chen, L., et al. J. Clin. Invest. 120 (4) :1178-1191 (2010)
Background Reference 03
Ahel, D., et al. Science 325 (5945) :1240-1243 (2009)
Background Reference 04
Gottschalk, A.J., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (33) :13770-13774 (2009)
Other Product Names
Chromodomain-helicase-DNA-binding protein 1-like, Amplified in liver cancer protein 1, CHD1L, ALC1
Tested Applications
WB
Protein ID
311033359
Physical Properties
Liquid

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