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WWTR1 Antibody

CAT: 0223-58-471Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-471Size:400 µL
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Background
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
NCBI Gene ID
25937
Swiss Prot
Q9GZV5
Accession Number
Q9GZV5
Host
Rabbit
Reactivity
Human
Immunogen
This WWTR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 370-398 amino acids from the C-terminal region of human WWTR1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
WWTR1
NCBI Official Name
WW domain-containing transcription regulator protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Remue, E., et al. FEBS Lett. 584 (19) :4175-4180 (2010)
Background Reference 02
Strakova, Z., et al. Biol. Reprod. 82 (6) :1112-1118 (2010)
Background Reference 03
Cho, H.H., et al. J. Cell. Physiol. 223 (1) :168-177 (2010)
Background Reference 04
McGeachie, M., et al. Circulation 120 (24) :2448-2454 (2009)
Other Product Names
WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif, WWTR1, TAZ
Tested Applications
WB
Protein ID
67462080
Physical Properties
Liquid

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