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GAB3 Antibody

CAT: 0223-58-446Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-446Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GAB3 is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Two transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
139716
Swiss Prot
Q8WWW8
Accession Number
Q8WWW8
Host
Rabbit
Reactivity
Human
Immunogen
This GAB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-58 amino acids from the N-terminal region of human GAB3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
66 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
GAB3
NCBI Official Name
GRB2-associated-binding protein 3
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Background Reference 03
Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)
Background Reference 04
Barrett, J.C., et al. Nat. Genet. 41 (6) :703-707 (2009)
Other Product Names
GRB2-associated-binding protein 3, GRB2-associated binder 3, Growth factor receptor bound protein 2-associated protein 3, GAB3
Tested Applications
WB
Protein ID
74716251
Physical Properties
Liquid

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