Vesicular GABA transporter Antibody

• Background:

  The Vesicular GABA Amino Acid Transporter (VGAT) is responsible for transport of the inhibitory neurotransmitter into synaptic vesicles (McIntire et al., 1997) . The VGAT protein (also known as the Vesicular Inhibitory Amino Aid Transporter or VIAAT) is expressed in synaptic vesicles of both glycine and GABAergic synapses throughout the CNS (Chaudhry et al., 1998) . Expression of the VGAT protein changes during development and also in response to patterns of neuronal activity (De et al., 2005) .

• NCBI Gene ID:

  83612

• Swiss Prot:

  O35458

• Accession Number:

  O35458

• Host:

  Rabbit

• Reactivity:

  Rat, Dog, Bovine

• Immunogen:

  Peptide corresponding to amino acid residues from the N-terminal region of rat Vesicular GABA Amino Acid Transporter (VGAT) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity Purified

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Vesicular GABA transporter antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.

• Calculated Molecular Weight:

  53

• Symbol:

  Slc32a1

• NCBI Official Name:

  Solute carrier family 32 (GABA vesicular transporter), member 1

• NCBI Organism:

  Rattus norvegicus

• Background Reference 01:

  Chaudhry FA, Reimer RJ, Bellocchio EE, Danbolt NC, Osen KK, Edwards RH, Storm-Mathisen J (1998) The vesicular GABA transporter, VGAT, localizes to synaptic vesicles in sets of glycinergic as well as GABAergic neurons. J Neurosci 18:9733-9750.

• Background Reference 02:

  De GS, Schafer MK, Defamie N, Chen C, Ricci A, Weihe E, Varoqui H, Erickson JD (2005) Homeostatic scaling of vesicular glutamate and GABA transporter expression in rat neocortical circuits. J Neurosci 25:7121-7133.

• Background Reference 03:

  McIntire SL, Reimer RJ, Schuske K, Edwards RH, Jorgensen EM (1997) Identification and characterization of the vesicular GABA transporter. Nature (Lond) 389:870-876.

• Tested Applications:

  WB

• Protein ID:

  29428082

• Physical Properties:

  Liquid