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GAB3 Polyclonal Antibody

CAT: 0498-bs-13255RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-13255RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recrutiment to RTKs (13) . Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur (13) . This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab1-3 contain pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins (1,4,5) . The recruitment of signaling partners to Gab family members is phosphorylation dependent (1,4) . Insulin receptor and EGF-receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus (6,7) . The human Gab3 gene maps to chromosome Xq28 and encodes a 586 amino acid protein (5) .
Synonyms
Gab3; GAB3_HUMAN; GRB2-associated binder 3; GRB2-associated-binding protein 3; Growth factor receptor bound protein 2-associated protein 3.
Gene ID
139716
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Immunogen
31-130/586
Target
GAB3
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human GAB3
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
139716
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse

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