YTHD2 Antibody

• Background:

  YTHDF2 is a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosme 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene.

• NCBI Gene ID:

  51441

• Swiss Prot:

  Q9Y5A9

• Accession Number:

  Q9Y5A9

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This YTHD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-579 amino acids from the C-terminal region of human YTHD2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  62 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  YTHDF2

• NCBI Official Name:

  YTH domain-containing family protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Nguyen, T.T., et al. Genes Chromosomes Cancer 45 (10) :918-932 (2006)

• Background Reference 02:

  Cardelli, M., et al. J. Gerontol.Biol. Sci. Med. Sci. 61 (6) :547-556 (2006)

• Background Reference 03:

  Rush, J., et al. Nat. Biotechnol. 23 (1) :94-101 (2005)

• Background Reference 04:

  Stoilov, P., et al. Trends Biochem. Sci. 27 (10) :495-497 (2002)

• Other Product Names:

  YTH domain-containing family protein 2, CLL-associated antigen KW-14, High-glucose-regulated protein 8, Renal carcinoma antigen NY-REN-2, YTHDF2, HGRG8

• Tested Applications:

  WB

• Protein ID:

  41019527

• Physical Properties:

  Liquid