YTHD2 Antibody

CAT: 0223-58-440Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-58-440Size:400 µL
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Background
YTHDF2 is a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosme 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene.
NCBI Gene ID
51441
Swiss Prot
Q9Y5A9
Accession Number
Q9Y5A9
Host
Rabbit
Reactivity
Human
Immunogen
This YTHD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-579 amino acids from the C-terminal region of human YTHD2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
62 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
YTHDF2
NCBI Official Name
YTH domain-containing family protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Nguyen, T.T., et al. Genes Chromosomes Cancer 45 (10) :918-932 (2006)
Background Reference 02
Cardelli, M., et al. J. Gerontol.Biol. Sci. Med. Sci. 61 (6) :547-556 (2006)
Background Reference 03
Rush, J., et al. Nat. Biotechnol. 23 (1) :94-101 (2005)
Background Reference 04
Stoilov, P., et al. Trends Biochem. Sci. 27 (10) :495-497 (2002)
Other Product Names
YTH domain-containing family protein 2, CLL-associated antigen KW-14, High-glucose-regulated protein 8, Renal carcinoma antigen NY-REN-2, YTHDF2, HGRG8
Tested Applications
WB
Protein ID
41019527
Physical Properties
Liquid

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