Anti-YTHD2 YTHDF2 Antibody

CAT: 0519-A02621Size: 100 µLDry Ice: NoHazardous: No
CAT#:0519-A02621Size:100 µL
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Description
Boster Bio Anti-YTHD2 YTHDF2 Antibody catalog # A02621. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse.
Synonyms
YTH domain-containing family protein 2 ; CLL-associated antigen KW-14
Gene Name
YTHDF2
UniProt
Q9Y5A9
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Applications
WB, ELISA
Purification
YTHD2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/mL
Form
Liquid
Function
Specifically recognizes and binds N6-methyladenosine (m6A) -containing RNAs, and regulates mRNA stability (PubMed:24284625, PubMed:26046440, PubMed:26318451) . M6A is a modification present at internal sites of mRNAs and some non- coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661) . Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation (PubMed:24284625, PubMed:26046440) . Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (By similarity) . Also involved in haematopoietic stem cells specification: acts by binding to m6A-containing mRNAs, leading to decrease Notch dignaling and promote endothelial to haematopoietic transition (By similarity) . Also acts as a promoter of cap- independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (PubMed:26458103) . May inhibit replication of kaposis sarcoma-associated herpesvirus (KSHV) ; its role is however unclear and additional evidences are needed to confirm such results (PubMed:29109479) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
62334 MW
Gene Name Synonym
YTH domain-containing family protein 2
Subcellular Location
Cytoplasm, cytosol
Protein Name
YTH domain-containing family protein 2
Isotype
IgG
Contents
Liquid form in PBS containing 50% glycerol, and 0.02% sodium azide.

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