Anti-YTHD2 YTHDF2 Antibody

• Description:

  Boster Bio Anti-YTHD2 YTHDF2 Antibody catalog # A02621. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse.

• Synonyms:

  YTH domain-containing family protein 2 ; CLL-associated antigen KW-14

• Gene Name:

  YTHDF2

• UniProt:

  Q9Y5A9

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthesized peptide derived from part region of human protein

• Clonality:

  Polyclonal

• Applications:

  WB, ELISA

• Purification:

  YTHD2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Specifically recognizes and binds N6-methyladenosine (m6A) -containing RNAs, and regulates mRNA stability (PubMed:24284625, PubMed:26046440, PubMed:26318451) . M6A is a modification present at internal sites of mRNAs and some non- coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661) . Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation (PubMed:24284625, PubMed:26046440) . Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (By similarity) . Also involved in haematopoietic stem cells specification: acts by binding to m6A-containing mRNAs, leading to decrease Notch dignaling and promote endothelial to haematopoietic transition (By similarity) . Also acts as a promoter of cap- independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (PubMed:26458103) . May inhibit replication of kaposis sarcoma-associated herpesvirus (KSHV) ; its role is however unclear and additional evidences are needed to confirm such results (PubMed:29109479) .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  62334 MW

• Gene Name Synonym:

  YTH domain-containing family protein 2

• Subcellular Location:

  Cytoplasm, cytosol

• Protein Name:

  YTH domain-containing family protein 2

• Isotype:

  IgG

• Contents:

  Liquid form in PBS containing 50% glycerol, and 0.02% sodium azide.