CDCP1 Antibody

• Background:

  CDCP1 is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

• NCBI Gene ID:

  64866

• Swiss Prot:

  Q9H5V8

• Accession Number:

  Q9H5V8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CDCP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 704-732 amino acids from the C-terminal region of human CDCP1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  93 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CDCP1

• NCBI Official Name:

  CUB domain-containing protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  He, Y., et al. J. Biol. Chem. 285 (34) :26162-26173 (2010)

• Background Reference 02:

  Miyazawa, Y., et al. Cancer Res. 70 (12) :5136-5146 (2010)

• Background Reference 03:

  Mamat, S., et al. Oncol. Rep. 23 (5) :1221-1227 (2010)

• Background Reference 04:

  Fukuchi, K., et al. Mol. Pharm. 7 (1) :245-253 (2010)

• Other Product Names:

  CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135 kDa protein, SIMA135, Transmembrane and associated with src kinases, CD318, CDCP1, TRASK

• Tested Applications:

  WB

• Protein ID:

  317373455

• Physical Properties:

  Liquid