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MDS1 Antibody

CAT: 0223-58-431Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-431Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MDS1 is located at 3q26 170-400 kb upstream (telomeric) of EVI1 in the chromosomal region in which some of the breakpoints 5' of EVI1 have been mapped. MDS1 has been identified as a single gene as well as a previously unreported exon (s) of EVI1. MDS1 exists in normal tissues both as a unique transcript and as a normal fusion transcript with EVI1, with an additional 188 codons at the 5' end of the previously reported EVI1 open reading frame. In cells with translocation t (3;21), additional fusion transcripts are AML1-MDS1 and AML1-MDS1-EVI1. EVI1 and MDS1 are involved in leukemia associated with chromosomal translocation breakpoints in the region between these genes.
NCBI Gene ID
2122
Swiss Prot
Q13465
Accession Number
Q13465
Host
Rabbit
Reactivity
Mouse
Immunogen
This MDS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the Central region of human MDS1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
19 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MECOM
NCBI Official Name
MDS1 and EVI1 complex locus protein MDS1
NCBI Organism
Homo sapiens
Background Reference 01
Gomez-Benito, M., et al. Br. J. Cancer 103 (8) :1292-1296 (2010)
Background Reference 02
Meyer, T.E., et al. PLoS Genet. (8) (2010) :
Background Reference 03
Goyama, S., et al. Int. J. Hematol. 91 (5) :753-757 (2010)
Background Reference 04
Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :
Other Product Names
MDS1 and EVI1 complex locus protein MDS1, Myelodysplasia syndrome 1 protein, Myelodysplasia syndrome-associated protein 1, MECOM, MDS1
Tested Applications
WB
Physical Properties
Liquid

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